Vascular Biology 2019 Program

Sunday, October 27

2:00-6:00pm

Pre-Conference Meeting for Trainees

Chairs: Arif Yurdagul, Columbia University and Xiaolei Liu, Northwestern University
Featured Speakers:

Martin Schwartz, Yale University
Going with the flow in vascular cell biology
Jan Kitajewski, University of Illinois at Chicago
Fate Determination - branching out, maturing, going with the flow

Panel Discussion: "Taking the Next Steps in Your Career"
with Zhiyu Dai, University of Arizona, Monica Lee, University of Illinois at Chicago and
Sathish Srinivasan, Oklahoma Medical Research Foundation

Trainee speakers to be selected from abstract submissions

Joint Session

7:15-8:45pm

Opening Session

Presentation of Travel Awards

Keynote Lecture: Hal Dietz, Johns Hopkins Medical Center
Leveraging nature's success: lessons from modifiers of cardiovascular disease

Earl P. Benditt Award Lecture:  William C. Sessa, Yale School of Medicine
Integration of endothelial function and lipid metabolism

Monday, October 28

Origins of the Vasculature

Christiana Ruhrberg, University College London
A novel source of endothelial cells for organ vascularization

Didier Stainier, Max Planck Inst for Heart & Lung Res
Endothelial behavior during development and regeneration

Intersection of Tissue Engineering and Computational Modeling

Alison Marsden, Stanford University
Computer models that direct new surgical approaches and predict pediatric vascular disease outcomes

Stephen Chan, University of Pittsburgh
Leveraging systems biology to decipher ECM-driven pulmonary vascular metabolic reprogramming

Concurrent Sessions

10:30am-12:15pm

Signaling in the Vasculature

Mark Kahn, University of Pennsylvania
Mechanisms of lymphatic vessel repair and regrowth

Luisa Iruela-Arispe, UCLA
How do vessels grow after tubulogenesis?

Disease modeling with Biomedical Engineering

Jay Humphrey, Yale University
From mouse to computational models of central artery diseases

Kurt Stenmark, University of Colorado
Tissue-informed engineering strategies for modeling human pulmonary diseases 

Networking Lunch – Meet the Professors

Concurrent Sessions

1:45-4:00pm

Blood Vessel Morphogenesis

Co-sponsored by the Microcirculatory Society

Victoria Bautch, University North Carolina Chapel Hill
How blood vessels control their own destiny

Ondine Cleaver, UT Southwestern Medical Center
How vessel tubes are made and maintained

Brant Weinstein, NICHD/NIH
Vessel morphogenesis in the zebrafish brain

Vascular Calcification and Valve Development

Elena Aikawa, Brigham & Women’s Hospital/HMS
3D modeling to engineer and cure cardiovascular calcification

Raul Guzman, Beth Israel Deaconess Medical Center
Role of MMPs in arterial calcification

Nano-Talks: Late breaking submissions (ten 5-minute talks)

Poster Session 1

Tuesday, October 29

8:30-10:00am

Lymphangiogenesis

Co-sponsored by the Microcirculatory Society

Taija Mäkinen, Uppsala University
Vascular-bed specific mechanisms of lymphatic development and disease

Sathish Srinivasan, Oklahoma Med Research Fndn
Mechanisms of Wnt/beta-catenin signaling in lymphatic vascular development

Extracellular Matrix and Disease

Sarah Heilshorn Stanford University
Extracellular matrix and 3-D printing: A combined approach to vascular regeneration

Suneel Apte, Lerner Research Institute, Cleveland Clinic
Extracellular matrix and its proteolytic turnover in vascular wall disorders

Concurrent Sessions

10:30am-12:15pm

Artery-Vein Differentiation

Kristy Red-Horse, Stanford University
Development and regeneration of coronary arteries

Karen Hirschi, Yale School of Medicine
Regulation of endothelial cell specification

MCS Session: Microphysiological Models of the Microcirculation

Roger Kamm, Massachusetts Institute of Technology
Transport properties of a model blood-brain barrier

Jenny Munson, Virginia Tech
Therapeutic response models at tumor-lymphatic interface

Concurrent Sessions

1:45-3:45pm

Therapeutic Potential of Induced Pluripotent Stem Cell-derived ECs
Organized by Juan Melero-Martin

Joseph Wu, Stanford University
Stem cells & genomics- precision cardiovascular medicine

Juan Melero-Martin, Boston Children’s Hospital
Competent endothelial cells derived from human iPS cells with high efficiency

Mingxia Gu, Stanford University
iPSC derived vascular cells in disease modeling: Toward therapeutic discovery and precision medicine 

Bioengineering Vascularized Tissues for Regenerative Medicine
Organized by: Ngan Huang

Co-sponsored by the Microcirculatory Society

Sharon Gerecht, Johns Hopkins University
iPSC-derived vascular networks for therapeutics

Christopher S. Chen, Boston University
Engineering of vascular networks that induce therapeutic angiogenesis in ischemia

Ngan Huang, Stanford University
Induction of angiogenesis and endothelial fate differentiation using patterned nanofibrillar scaffolds

Bootcamp:  Tissue Clarity and LightSheet Imaging

Evening

Poster Session 2

Wednesday, October 30

Concurrent Sessions

8:30-10:00am

Mural Cell Origins and Functions

Yosuke Mukoyama, NHLBI/NIH
Neuro-vascular morphogenesis

Ralf H. Adams, Max-Planck Institute for Molecular Biomedicine
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signalling in endothelial cells

Mechanotransduction

Co-sponsored by the Microcirculatory Society

Martin Schwartz, Yale School of Medicine
Molecular mechanisms of endothelial fluid shear stress sensing and signaling

Concurrent Sessions

10:30am-12:00pm

MCS Session: Integrative Function in the Microcirculation

Shayn Peirce-Cottler, University of Virginia
Pericytes as integrators of tissue health status and microvascular function

Steve Segal, University of Missouri
Microvascular remodeling in skeletal muscle regeneration

Courtney Griffin, Oklahoma Med Research Foundation
Developmental crosstalk between macrophages and microvessels

Genetic Mechanisms Underlying Vascular Disease

Diana Milewicz, UTexas Health Sciences Center at Houston
Genes linked to thoracic aortic aneurysms implicate mechanotransduction as a primary disease driver

Beth Kozel, NHLBI/NIH
Elastic fiber disease - modifiers and mechanism

Joint Session

2:00-3:15pm

NAVBO Folkman and Springer Award Presentation and Lectures

Judah Folkman Award in Vascular Biology Lecture:  Anne Eichmann, Yale School of Medicine
Guidance of vascular barrier formation

Springer Award Recipient to be announced

Joint Session

3:30-5:45pm

Vascular Therapeutics:Vascular Transcriptomics - Discovery and Therapeutic Opportunities

Session Chairs: Jan Kitajewski, University of Illinois at Chicago and Nicholas Gale, Regeneron

Henar Cuervo, University of Illinois at Chicago
Notch signaling in retinal pericytes

Christer Betsholtz, Karolinska Institute/Uppsala University
Vascular single-cell transcriptomics

Amber Stratman, Washington University in St. Louis
Transcriptomic analysis of vascular smooth muscle cells in zebrafish

Qi Zhao, Regeneron
Transcriptomic analysis of tumor vasculature

7:15-10:00pm

Anniversary Celebration!!

 Thursday, October 31

Joint Session

8:30am-12:30pm

Emerging Technologies and Imaging

Co-programmed by the Microcirculatory Society

Nathan Lawson, University of Massachusetts
Investigating cardiovascular cell heterogeneity in the zebrafish, one cell at a time

Rui Benedito, Centro Nacional de Investigaciones Cardiovasculares
Using multispectral genetic mosaics to enlighten endothelial heterogeneity during angiogenesis

Todd McDevitt, University of California, San Francisco
Engineering cardiac microtissues to interrogate mechanisms of heterotypic interactions

Song Hu, University of Virginia
Listening with light: photoacoustic microscopy of the microcirculation in vivo

Several abstracts will be added to this session