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Jeffrey S. Isenberg, M.D., M.P.H. - Principal Investigator

Division of Pulmonary, Allergy and Critical Care Medicine,
Department of Medicine, and the Vascular Medicine Institute of the University of Pittsburgh School of Medicine

lab photo 11 22 125F913950FEF3

Jeff Isenberg, M.D. MPH Principal Investigator
Enrico M. Novelli, MD Assistant Professor
Natasha M. Rogers, MD, PhD Post Doctoral fellow
Maryam Sharifi-Sanjani, PhD Post Doctoral fellow
Heather E. Knupp, MS Research specialist
Lisa R. Negly Undergraduate
Daniel P. Dempe Undergraduate
Johannes Kutten MD-PhD student

Primary Research: Our lab focuses on ligand receptor interactions that promote cellular and tissue injury. We are presently investigating a widely expressed cell receptor CD47, and its high affinity ligand thrombospondin-1 and the role this pathway plays in several diseases including pulmonary arterial hypertension, sickle cell disease, systemic arterial vasculopathy, heart failure and acute kidney injury. .

Visit the lab's web site: http://www.vmi.pitt.edu/isenberglab.html

Recent Publications:

Thrombospondin-1 Regulates Blood Flow via CD47 Receptor-Mediated Activation of NADPH Oxidase 1. Csányi G, Yao M, Rodríguez AI, Ghouleh IA, Sharifi-Sanjani M, Frazziano G, Huang X, Kelley EE, Isenberg JS, Pagano PJ. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2966-73. doi: 10.1161/ATVBAHA.112.300031. Epub 2012 Oct 18. PMID:23087362

Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury. Rogers NM, Thomson AW, Isenberg JS. J Am Soc Nephrol. 2012 Sep;23(9):1538-50. doi: 10.1681/ASN.2012020137. Epub 2012 Aug 2. PMID: 22859854

Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates. Novelli EM, Kato GJ, Ragni MV, Zhang Y, Hildesheim ME, Nouraie M, Barge S, Meyer MP, Hassett AC, Gordeuk VR, Gladwin MT, Isenberg JS. Am J Hematol. 2012 Mar;87(3):326-30. doi: 10.1002/ajh.22274. Epub 2012 Feb 8. PMID:22318901

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Bauer PM, Bauer EM, Rogers NM, Yao M, Feijoo-Cuaresma M, Pilewski JM, Champion HC, Zuckerbraun BS, Calzada MJ, Isenberg JS. Cardiovasc Res. 2012 Mar 15;93(4):682-93. Epub 2012 Jan 2. PMID:22215724

The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47. Roberts DD, Miller TW, Rogers NM, Yao M, Isenberg JS. Matrix Biol. 2012 Apr;31(3):162-9. Epub 2012 Jan 14. Review. PMID:22266027

Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management. Rogers NM, Yao M, Novelli EM, Thomson AW, Roberts DD, Isenberg JS. Am J Physiol Renal Physiol. 2012 Oct;303(8):F1117-25. doi: 10.1152/ajprenal.00359.2012. Epub 2012 Aug 8. PMID:22874763