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Calvin P. Vary, Ph.D. - Principal Investigator

Maine Medical Center Research Institute


The Calvin Vary Lab

Eric Tweedie

Barbara Conley

MaryLynn Fitzsimmons

Kira Young

Calvin Vary, Ph.D.


Primary Research:
Endothelial cell Biology and hereditary hemorrhagic telangiectasia (HHT)

Visit the lab's web site: www.mmcri.org/vary

Recent Publications:
Young K, Conley B, Romero D, Tweedie E, O'Neill C, Pinz I, Brogan L, Lindner V, Liaw L, Vary CP. Bmp9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood. 2012;120:4263-4273

Prudovsky I, Vary CP, Markaki Y, Olins AL, Olins DE. Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes. Nucleus. 2012;3:200-210

Contois L, Nugent DP, Caron JM, Cretu A, Tweedie E, Akalu A, Osman I, Liebes L, Friesel R, Rosen CJ, Vary C, Brooks PC. Insulin-like growth factor binding protein-4 (igfbp-4) differentially inhibits growth factor-induced angiogenesis. J. Biol. Chem. 2012;287:1779-1789

Venkatesh D, Fredette N, Rostama B, Tang Y, Vary CP, Liaw L, Urs S. Rhoa-mediated signaling in notch-induced senescence-like growth arrest and endothelial barrier dysfunction. Arterioscler Thromb Vasc Biol. 2011

Tang Y, Yang X, Friesel RE, Vary CPH, Liaw L. Mechanisms of tgfβ-induced differentiation in human vascular smooth muscle cells. Journal of Vascular Research. 2011;48:485–494

Romero D, O'Neill C, Terzic A, Contois L, Young K, Conley BA, Bergan RC, Brooks PC, Vary CPH. Endoglin regulates cancer-stromal cell interactions in prostate tumors. Cancer Res. 2011;71:3482–3493

Collaborative Relationships:
Lucy Liaw, PhD, MMCRI
Peter Brooks, PhD, MMCRI
Ilka Pinz, PhD, MMCRI
Volkhard Lindner, MD. PhD., MMCRI
Robert Friesel, PhD, MMCRI
Igor Prudovsky, PhD, MMCRI
Raymond Bergan, MD, Northwestern University School of Medicine

Recent Presentations:
NAVBO Workshops in Vascular Biology 2012 - Kira Young