• Image
  • Image
  • Image
  • Image

Volkhard Lindner, M.D., Ph.D. - Principal Investigator

Maine Medical Center Research Institute

lindner lab

The Lindner Lab

Qiaozeng Wang, B.S.  
Volkhard Lindner, M.D., Ph.D.  
J. Patrizia Stohn, Ph.D.  
Nicole J. Perreault, B.S.  
Katrina Abramo, B.S.  
Grazina A. Mangoba, B.S., HTL (ASCP)   


Primary Research:

Since the late 1990ies research efforts in our laboratory have been focused on the understanding of the functions of the Collagen Triple Helix Repeat Containing-1 (Cthrc1), a molecule discovered in our laboratory in 1999 in the adventitia of injured arteries. We recently found that Cthrc1 is a novel hormone with expression in the hypothalamus, the pituitary gland and in bone under homeostatic conditions. Cthrc1 null mice have increased levels of glycogen in skeletal muscle and liver, and these mutants develop steatosis. Our long term goals are to understand the functions of Cthrc1 in health and disease and explore whether abnormal Cthrc1 levels are linked to alter physiology or pathology.

Visit the lab's web sites:
http://www.mmcri.org/home/webSubContent_p.php?list=webcontentlive&catID=3&subCatID=9&userID=lindnv&id=201
and
http://www.mmcri.org/home/webSubContent.php?list=webcontentlive&id=132&catID=3&subCatID=14

Trainees:

J.Parizia Stohn, Ph.D.-postdoctoral fellow; Emily Morin-undergraduate student

Recent Publications:
Stohn JP, Perreault NG, Wang Q, Liaw L, Lindner V. Cthrc1, a novel circulating hormone regulating metabolism. PLoS One 2012;7(10):e47142. doi:10.1371/journal.pone.0047142. Epub 2012 Oct 8.

Cuttler AS, LeClair RJ, Stohn JP, Wang Q, Sorenson CM, Liaw L and Lindner V. Characterization of Pdgfrb-Cre transgenic mice reveals reduction of ROSA26 reporter activity in remodeling arteries. Genesis 2011; 49:673-680.

Pyagay P, Heroult M, Wang Q, Lehnert W, BeldenJ, Liaw L, Friesel RE, Lindner V. Collagen triple helix repeat containing 1 (Cthrc1), a novel secreted protein in injured and diseased arteries inhibits collagen expression and promotes cell migration. Circ Res 2005; 96:281-268.