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Colleen Brophy, M.D.
Joyce Cheung-Flynn, Ph.D. and
Padmini Komalavilas, Ph.D.

VA Medical Center, Nashville TN
Vanderbilt University Medical Center
Department of Surgery

brophylab

Primary Research:

Our lab is focused on the mechanisms of injury associated with harvest, preparation, and preservation of human saphenous vein grafts. We are also interested in calcium independent smooth muscle relaxation. The laboratory has generated 3 patents and there are three therapeutics in preclinical development.

Lab Members:

Colleen Brophy, MD
Joyce Cheung-Flynn, PhD
Padmini Komalavilas PhD
Weifeng Luo, PhD
Eric Wise, MD
Kyle Hocking
Sidney Pedigo
Matthew Beebe
Bridgette Corsa
Alex Banathy
Daniel Feldman

Recent Publications:

Hocking KM, Baudenbacher FJ, Putumbaka G, Venkatraman S, Cheung-Flynn J, Brophy CM, Komalavilas P. Role of cyclic nucleotide-dependent actin cytoskeletal dynamics: [Ca2+]i and force suppression in forskolin-pretreated porcine coronary arteries. Plow One 8:e60986, 2013

Osgood MJ, Hocking KM, Voskrensensky IV, Li F, Komalavilas P, Cheung-Flynn J, Brophy, CM Surgical vein preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein. J Vasc Surg, epub ahead of print.

Li FD, Eagle S, Brophy C, Hocking KM, Osgood M. Komalavilas P, Cheung-Flynn J. Pressure control during preparation of saphenous veins prevents endothelial injury and reduces neointima formation. JAMA Surgery, In Press