Maria Bloksgaard, Ph.D.
Department of Cardiovascular and Renal Research
Vascular Physiology and Pharmacology
Institute of Molecular Medicine
University of Southern Denmark
The lab’s main research goal is to understand and decipher how metabolic and oxidative stress in the vascular wall initiate functional changes in smooth muscle and endothelial cells (acute effects) promoting vascular dysfunction and remodeling of the extracellular matrix (chronic effects) in resistance arteries from ageing, hypertensive, diabetic patients.
Resistance arteries obtained from patients with and without ischemic heart disease, hypertension and diabetes are studied alive, ex vivo by means of functional fluorescence microscopy, biomechanical testing and pharmacological methods (acute effects of pharmacological interventions). Meta-analyses are conducted on data obtained for a broad range of patients to investigate the chronic vascular effects of antihypertensive and antidiabetic pharmacological treatments in the ageing human microcirculation based on acquired structural/functional data in relation to patients’ information on disease, pharmacotherapy, biochemistry, and arterial wall proteome analyses.
Members of the laboratory:
Jo De Mey (Professor and team mate/shared laboratory)
Atlanta Elie (PhD Student)
Maximilian Matthies (PhD Student)
Inger Nissen (technician)
Kristoffer Rosenstand (technician)
Maria Anthonsen (lab-tech student)
Lasse Nielsen (MSc student)
Mikkel Larsen (MSc student)
- Leurgans TM, Bloksgaard M, Irmukhamedov A, Riber LP, De Mey JGR. Relaxing Responses to Hydrogen Peroxide and Nitric Oxide in Human Pericardial Resistance Arteries Stimulated with Endothelin-1 Basic Clin Pharmacol Toxicol. 2017 Jul 7. doi: 10.1111/bcpt.12843. [Epub ahead of print]
- BloksgaardM, Leurgans TM, Spronck B, Heusinkveld MHG, Thorsted B, Rosenstand K, Nissen I, Hansen UM, Brewer JR, Bagatolli LA, Rasmussen LM, Irmukhamedov A, Reesink KD, De Mey JGR, Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries, Am J Physiol Heart Circ Physiol. 2017 Apr 21:ajpheart.00110.2017. doi: 10.1152/ajpheart.00110.2017. [Epub ahead of print]
- Bai B, Man AW, Yang K, Guo Y, Xu C, Tse HF, Han W, BloksgaardM, De Mey JG, Vanhoutte PM, Xu A, Wang Y. Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.Oncotarget. 2016 May 29. doi: 10.18632/oncotarget.9687. [Epub ahead of print]
- Leurgans T, BloksgaardM, Fredgart MH, Lyck Hansen M, Melholt Rasmussen L, Irmukhamedov A, De Mey J.G.R. Endothelin-1 shifts the mediator of bradykinin-induced relaxation from NO to H2O2 in resistance arteries from cardiovascular disease patients. Br J Pharmacol. 2016 Feb 23. doi: 10.1111/bph.13467. [Epub ahead of print]
- Thorsted B, BloksgaardM, Groza A, Schousboe LP, FærgemanNJ, Sørensen JA, Svane-Knudsen V, Brewer JR. Biochemical and Bioimaging Evidence of Cholesterol in Acquired Cholesteatoma,Ann Otol Rhinol Laryngol. 2016 Aug;125(8):627-33. doi: 10.1177/0003489416642784. Epub 2016 Apr 15
- Bek S, Neess D, Dixen K, BloksgaardM, Marcher AB, Chemnitz J, Færgeman N, Mandrup S,Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice, JLR2015 Sep;56(9):1738-46.
- Bloksgaard M, Leurgans TM, Nissen I, Jensen PS, Hansen ML, BrewerJR, Bagatolli LA, Marcussen N, Irmukhamedov A, Rasmussen LM, De Mey JGR, Elastin organization in pig and cardiovascular disease patients’ pericardial resistance arteries, J. Vasc.Res.2015 (1): 1-11 DOI: 10.1159/000376548
- Univ. Missouri-Columbia (Columbia, MO)
- NAVBO Vascular Biology (Asilomar CA)
- ESM-EVBO (Geneva, CH)
- DKPharma (Odense DK)
- MOVD (Rochester MN)
- IVBM (Boston MA)
- Univ. Missouri-Columbia (Columbia MO)
- DaCRA (Sonderborg DK)