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Jessica Wagenseil, DSc

Associate Professor
Mechanical Engineering and Materials Science
Washington University in St. Louis
St. Louis, MO

Primary Research:

Our lab studies vascular mechanics with a focus on elastic fiber defects in large arteries. We are interested in how genetic mutations in elastic fiber proteins affect arterial mechanical properties and lead to diseases such as arterial stiffening, hypertension, and thoracic aortic aneurysms. We are also interested in the interplay between hemodynamic forces and aortic development and maturation.

Lab Web Site: https://wagenseil.mems.wustl.edu/

Members of the laboratory: 

Gabriela Espinosa, Ph.D student
Austin Cocciolone, Ph.D. student
Jie Hawes, Ph.D. student
Ramin Balouchzadeh, Ph.D. student
Elizabeth Johnson, technician
Humza Ismail, B.S./M.S. student
Connie Lee, B.S./M.S. student
Shawn Pavey, B.S. student

 

Wagenseil Lab 2018 3

 

Recent Publications:

  • “Reduced embryonic blood flow impacts extracellular matrix deposition in the maturing aorta”. Espinosa MG, Taber LA, Wagenseil JE. Dev Dyn. 2018 Apr 26. doi: 10.1002/dvdy.24635. [Epub ahead of print] PMID: 29696727
  • “Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness”. Knutsen RH, Beeman SC, Broekelmann TJ, Liu D, Tsang KM, Kovacs A, Ye L, Danback JR, Watson A, Wardlaw A, Wagenseil JE, Garbow JR, Shoykhet M, Kozel BA. Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H18-H32. doi: 10.1152/ajpheart.00683.2017. Epub 2018 Mar 2. PMID: 29498532
  • “Effects of increased arterial stiffness on atherosclerotic plaque amounts”. Stoka KV, Maedeker JA, Bennett L, Bhayani SA, Gardner WS, Procknow JD, Cocciolone AJ, Walji TA, Craft CS, Wagenseil JE. J Biomech Eng. 2018 May 1;140(5). doi: 10.1115/1.4039175. PMID: 29392300