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Clint Miller, Ph.D.

Center for Public Health Genomics
University of Virginia
Charlottesville, VA

Primary Research:

The Miller Lab is located in the Center for Public Health Genomics at the University of Virginia. Our lab focuses on genetic and environmental risk factors for coronary artery disease and other complex cardiovascular diseases using a combination of computational systems genomics, single-cell -omics, and genetic/drug perturbations in vitro. We integrate state-of-the-art computational and functional genomic analyses with vascular physiology to study causal regulatory networks driving vascular disease processes. We have assembled a biobank of vascular tissue samples from a diverse cohort of normal and diseased patients with a spectrum of phenotypes to facilitate our discovery approaches. Our primary goals are to identify novel markers to better classify patients with cardiovascular disease as well as inform tailored treatments that target dysregulated pathways in the vessel wall.

Lab Web Site: http://millerlab.org/

Members of the laboratory: 
Adam Turner, Postdoctoral Fellow
Chani Hodonsky, Postdoctoral Fellow
Doris Wong, PhD Student
Yipei Song, PhD Student
Wei Feng Ma, MD/PhD Student
Nelson Barrientos, Laboratory Specialist
Gaelle Auguste, Research Scientist
José Verdezoto Mosquera, Visiting PhD Student
Ruben Methorst, Visiting MS Student
Yixuan Chen, Undergraduate Student
Priya Batheja, Undergraduate Student
Jasmine Dogu, Undergraduate Student
Pranavi Gopanapalli, Undergraduate Student
David Mai, Undergraduate Student
Arfa Iftikhar, Undergraduate Student
Humaira Halim, Undergraduate Student
Saranya Kasinathuni, Undergraduate Student

 MillerLab photo2

Recent Publications:

  • Ma WF, Hodonsky CJ, Turner AW, Wong D, Song Y, Barrientos NB, Miller CL. Single-cell RNA-seq analysis of human coronary arteries using an enhanced workflow reveals SMC transitions and candidate drug targets. bioRxiv. 2020 doi: https://doi.org/10.1101/2020.10.27.357715
  • Aherrahrou R, Guo L, Nagraj VP, Aguhob A, Hinkle J, Chen L, Yuhl Soh J, Lue D, Alencar GF, Boltjes A, van der Laan SW, Farber E, Fuller D, Anane-Wae R, Akingbesote N, Manichaikul AW, Ma L, Kaikkonen MU, Björkegren JLM, Önengüt-Gümüşcü S, Pasterkamp G, Miller CL, Owens GK, Finn A, Navab M, Fogelman AM, Berliner JA, Civelek M. Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. Circ Res. 2020 Dec 4;127(12):1552-1565. PMID: 33040646
  • Wang Y, Nanda V, Direnzo D, Ye J, Xiao S, Kojima Y, Howe KL, Jarr KU, Flores AM, Tsantilas P, Tsao N, Rao A, Newman AAC, Eberhard AV, Priest JR, Ruusalepp A, Pasterkamp G, Maegdefessel L, Miller CL, Lind L, Koplev S, Björkegren JLM, Owens GK, Ingelsson E, Weissman IL, Leeper NJ. Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15818-15826. PMID: 32541024
  • Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nat Med. 2019 Aug;25(8):1280-1289.
  • Wong D, Turner AW, Miller CL. Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1006-1017.

Collaborative Relationships:

Member of Leducq PlaqOmics network (www.plaqomics.com), Trans-Omics for Precision Medicine (www.nhlbiwgs.org), Multi-Ethnic Study of Atherosclerosis (www.mesa-nhlbi.org), and International Common Disease Alliance (www.icda.bio)

Recent Presentations:

ASHG 2020, Platform presentations (Chani Hodonsky (postdoc), Adam Turner (postdoc), Nelson Barrientos (Lab specialist)

Lab Motto:

“Where there’s a will, there’s a way”..and “It’s always Miller Time!”