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The Gerhardt lab is a joint venture between the Vascular Biology Lab (VBL) in London and the Vascular Patterning Lab (VPL) in Leuven seeking to foster new insights by establishing an interdisciplinary team that can draw inspiration from the diverse scientific environment present at the LRI and the VIB.

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The primary focus of the laboratory is to delineate the role of the renin-angiotensin system on vascular pathology. In collaboration with the laboratory of Dr. Lisa Cassis during the early days of arriving at the University of Kentucky, initial studies examined the role of blood pressure in atherosclerosis.

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The Dardik laboratory studies the healing and function of blood vessels and synthetic blood vessel substitutes that are used in patients having vascular bypass surgery.

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Since the late 1990ies research efforts in our laboratory have been focused on the understanding of the functions of the Collagen Triple Helix Repeat Containing-1 (Cthrc1), a molecule discovered in our laboratory in 1999 in the adventitia of injured arteries.

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Identification of pro and anti-inflammatory mechanisms in the vessel wall. Induction of the Th2 anti-inflammatory phenotype by resident vascular cells. Angiogenic mechanisms of anti-inflammatory interleukins.

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