Michael V. Autieri, Ph.D.

Independence Blue Cross Cardiovascular Research Center
Department of Physiology
Temple University School of Medicine

Mike Autieri, Ph.D.:  Principal Investigator
Sheri Kelemen: Lab manager
Khatuna Gabunia, Ph.D.: Post Doctoral fellow
Stephen Ellison MD/PhD: candidate
Ross England MD/PhD: candidate
Alex Miecyjak MS: candidate
James Richards: Graduate Student

Lab Motto:    Don't Panic!!!

Primary Research:
Identification of pro and anti-inflammatory mechanisms in the vessel wall. Induction of the Th2 anti-inflammatory phenotype by resident vascular cells. Angiogenic mechanisms of anti-inflammatory interleukins.

Visit the lab's web site: http://www.temple.edu/medicine/faculty/a/autieri.asp?pms=

Recent Publications:
Interleukin-19 (IL-19) Induces Heme Oxygenase-1 (HO-1) Expression and Decreases Reactive Oxygen Species in Human Vascular Smooth Muscle Cells. Gabunia K, Ellison SP, Singh H, Datta P, Kelemen SE, Rizzo V, Autieri MV. J Biol Chem. 2012 Jan 20;287(4):2477-84.

NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis. Berglund LM, Kotova O, Osmark P, Grufman H, Xing C, Lydrup ML, Goncalves I, Autieri MV, Gomez MF. Cardiovasc Res. 2012 Mar 1;93(3):414-23.

Increased atherosclerosis and vascular smooth muscle cell activation in AIF-1 transgenic mice fed a high-fat diet. Sommerville LJ, Kelemen SE, Ellison SP, England RN, Autieri MV. Atherosclerosis. 2012 Jan;220(1):45-52.

A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature. Takaguri A, Kimura K, Hinoki A, Bourne AM, Autieri MV, Eguchi S. Hypertension. 2011 Apr;57(4):841-5.

Anti-inflammatory cytokine interleukin-19 inhibits smooth muscle cell migration and activation of cytoskeletal regulators of VSMC motility. Gabunia K, Jain S, England RN, Autieri MV. Am J Physiol Cell Physiol. 2011 Apr;300(4):C896-906.

The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells. Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):167-75.

Collaborative Relationships:
Temple University -
Satoru Eguchi, MD,PhD, Victor Rizzo, PhD, Rosario Scalia MD,PhD

Lund University, Sweden -
Maria F. Gomez, PhD

Recent Presentations:
Department of Pharmacology and Toxicology, Georgia Health Sciences University
Department of Physiology, University of Tennessee