Stryder Meadows, Ph.D.

Assistant Professor
Department of Cell and Molecular Biology
Tulane University
New Orleans, LA

Primary Research:

Our lab uses a combination of mouse genetics and in vitro experimental approaches to understand the basic molecular mechanisms of vascular development and disease. A main focus of the lab is to elucidate the molecular pathways associated with the vascular disorder Hereditary Hemorrhagic Telangiectasia (HHT). In particular, we aim to identify TGF downstream targets that are involved in the formation of arteriovenous malformations (AVMs) that occur in HHT patients. We are also interested in defining the mechanisms of blood vessel fusion, as well as identifying genes with novel roles in vascular biology. Our favorite vascular model is the mouse retina, but we also investigate embryonic development.

Lab Web Site: https://meadowslab.squarespace.com

Members of the laboratory:

Angela Crist (PhD student)
Nehal Patel (PhD student)
Dawn Westhoff (PhD student)
Xingyan Zhou (PhD student)
Kelsey Carter (Lab Research Technician)
Avery Blanks (Lab Research Technician)
Josh Kirkorsky (undergraduate student) - not pictured
Hannah Broussard (undergraduate student)
Amanda Lee (undergraduate student)

Recent Publications:

• Suarez-Martinez AD, Bierschenk S, Huang K, Kaplan D, Bayer CL, Meadows SM, Sperandio M and Murfee WL. A Novel Ex Vivo Mouse Mesometrium Culture Model for Investigating Angiogenesis in Microvascular Networks. (Journal of Vascular Research, accepted February 19th, 2018).
• Crist AM, Lee AR, Patel NR, Westhoff, DE and Meadows SM. (2018). Vascular Deficiency of Smad4 Causes Arteriovenous Malformations: a Mouse Model of Hereditary Hemorrhagic Telangiectasia. Angiogenesis, DOI: 10.1007/s10456-018-9602-0.
• Lee HW, Chong DC, Ola R, Dunworth WP, Meadows SM, Ka J, Kaartinen VM, Qyang Y, Cleaver O, Bautch VL, Eichmann A and Jin SW. (2017). Distinct requirement of Alk2/ACVR1 and Alk3/BMPR1A in Bone Morphogenetic Protein induced retina angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(4): 657-663.
• Crist AM, Young C and Meadows SM. (2017). Characterization of Arteriovenous Identity in the Developing Neonate Mouse Retina. Gene Expression Patterns, 3(23-24): 22-31. doi: 10.1016/j.gep.2017.01.002.
• Barry D, Xu K, Meadows SM, Zheng Y, Norden P, Davis G and Cleaver O. (2015).  Cdc42 is required for cytoskeletal support of cell adhesion during blood vessel formation. Development, 142(17):3058-70.
• Meadows SM and Cleaver O. (2015).  Annexin A3 regulates early blood vessel formation. PLoS One, 10(7):e0132580.

Recent Presentations:

• “A novel Smad4 model of Hereditary Hemorrhagic Telangiectasia (HHT) link angiopoietin/TEK signaling to the formation of arteriovenous malformations.” Vascular Biology (NAVBO). Pacific Grove, CA, October 16th, 2017.