Amber Stratman, Ph.D.

Department of Cell Biology and Physiology
Washington University School of Medicine
St. Louis, MO

Primary Research:

My research group is interested in the mechanosensitive inputs that direct mural cell recruitment to arteries during development. We are particularly interested in how mechanosensitive proteins couple force inputs from a 3D environment to alter transcription and gene expression in developing tissues. We use zebrafish and in vitro 3D modeling assays to mechanistically dissect these events.

Laboratory Website: https://stratmanlab.wustl.edu

Members of the laboratory:

Javier Abello (postdoc)
Sarah Colijn (postdoc)
Zarek Burton (master's student/technician)
Ying Yin (technician)
Bharadwaj Chintalapati (undergraduate researcher)
Alli Levitas (undergraduate researcher)

Recent Publications:

• Stratman AN, Pezoa SA, Farrelly OM, Castranova D, Dye LE, Butler MG, Sidik H, Talbot WS and Weinstein BM. Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta. Development. 2017:144(1): 115-127.
• Stratman AN, Farrelly OM, Miller MF, Mikelis CM, Wang Z, Burns MC, Pezoa SA, Pham VN, Castranova D, Davis AE, Yano JJ, Kilts TM, Davis GE, Gutkind JS and Weinstein BM. Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. In press- Nature Communications.
• Stratman AN, Burns MC, Farrelly OM, Davis AE, Li W, Pham VN, Castranova D, Yano JJ, Goddard LM, Nguyen O, Venero Galanternik M, Bolan TJ, Kahn ML, Mukouyama Y, and Weinstein BM. A Molecular Pathway for Arterial-Specific Association of Vascular Smooth Muscle Cells. bioRxiv. (https://www.biorxiv.org/content/10.1101/2019.12.27.889782v1)