Eric Camerer, PhD
October 2, 2022
Inserm Research DirectorParis Cardiovascular Research Center
INSERM U970
Université Paris Cité
Paris, France
Primary Research:
Our group studies roles for G protein-coupled receptor (GPCR) signaling induced by serine proteases and the bioactive lipid sphingosine 1-phosphate in development and disease. We explore how these GPCRs are engaged to regulate vascular patterning and function and their potential as therapeutic targets for cardiovascular diseases. An important focus of our group is to understand how sphingosine 1-phosphate and serine proteases influence the patency, barrier function and reactivity of blood vessels, and the impact of these signaling pathways on tissue perfusion and vascular integrity in disease conditions.
We form a team at the Paris Cardiovascular Research Center together with the group of Pierre-Louis Tharaux, which studies the role of cell communication in pathologies that either cause or arise secondary to glomerular capillary dysfunction. Our groups share a common interest in how local signalling crosstalk regulates vascular integrity and how the loss of vascular integrity exacerbates inflammatory diseases, and we both use genetic and pharmacological tools to address these questions in mouse models.
Laboratory web site URL:
http://parcc.inserm.fr/research-teams/team/tharaux-camerer/
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