Gediminas Cepinskas, DVM, PhD
October 1, 2023
The Vascular Inflammation Laboratory
Centre for Critical Illness Research
Lawson Health Research Institute
and
Depts. Medical Biophysics/Anatomy & Cell Biology
Western University
Primary Research:
Research at the Vascular Inflammation laboratory (Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada) under supervision of Dr. Cepinskas, focuses on pathophysiology of systemic disorders such as sepsis/COVID-19, multi-organ trauma and ischemia-reperfusion injury, with the prime focus on inflammatory activation/dysfunction of organ-specific vascular endothelial cells.
In parallel, contribution of inflammatory cells (e.g., neutrophils; with respect to the role of proteolytic and oxidative stresses) to vascular injury/dysfunction is also investigated.
Cellular/molecular mechanisms of disorders mentioned above are investigated in the preclinical models employing both experimental animals and primary organ-specific (e.g. cerebrovascular, pulmonary or skeletal muscle) vascular endothelial cell cultures or vascular endothelial cell-neutrophil co-culture systems in the presence of the “blood flow” conditions in vitro.
Gaseous transmitters (e.g. carbon monoxide / carbon monoxide releasing molecules; CORMs) are investigated as potential modulators/therapy of systemic inflammation.
Laboratory web site URL:
https://www.lawsonresearch.ca/research-area/critical-illness
https://www.lawsonresearch.ca/scientist/dr-gediminas-cepinskas
Collaborative Relationships:
Ongoing research partnership with:
Dr. Douglas D. Fraser (https://www.schulich.uwo.ca/paediatrics/about_us/people/faculty/fraser_doug.html)
- COVID-19, Sepsis, Traumatic Brain Injury, Blood-Brain-Barrier dysfunction, Diagnostic Biomarkers, COVID-19 Inflammatory Blood Biomarkers
Drs. Abdel Lawendy and Aurelia Bihari-Dencev (https://www.lhsc.on.ca/media/11287/download?attachment)
- Carbon monoxide releasing molecules (CORMs) in treatment of Limb Compartment Syndrome
Drs. Partick Luke and Alp Sener (https://www.schulich.uwo.ca/urology/people/faculty/Luke,%20Patrick.html)
(https://www.schulich.uwo.ca/urology/people/faculty/Sener,%20Alp.html)
- Carbon monoxide releasing molecules (CORMs) in kidney transplantation
Dr. Kevin Shoemaker (https://www.uwo.ca/bmi/investigators/j-kevin-shoemaker.html)
- Cerebrovascular outcomes in ischemic heart disease patients undergoing cardiac rehabilitation
Laboratory Motto:
“Towards an Inflammation-free body!”