Strategic Partners
Poster Session Sponsor
Event Partner
Academic Contributors
The Center for Cardiovascular Immunology Research
at the Peter Munk Cardiac Centre
Contributors
Funding for this conference was made possible (in part) by 1R13HL167547-01A1 from the National Heart Lung and Blood Institute (NHLBI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
Vascular Biology 2023
October 15-19, 2023
Newport Harbor Island Resort (formerly Gurney's Resort and Marina)
Co-Sponsored with the Microcirculatory Society
Vascular Biology 2023 will focus on these themes:
Developmental Vascular Biology and Genetics*
Inflammation*
Matrix Biology and Bioengineering*
Signaling*
Microcirculation
Imaging
Translational Research
* these were commonly referred to as the NAVBO Workshops
Vascular Biology 2023 – Preliminary Program | ||
Day 1 – Sunday, October 15 | ||
1:00 – 5:00pm | PRE-CONFERENCE FOR TRAINEES Organizers: Tendai Hunyenyiwa, Medical College of Wisconsin and Heena Kumra, Massachusetts General Hospital Featured Speakers: | |
6:30 – 9:00pm | Keynote Lecture: Following the path of vascular growth - Luisa Iruela-Arispe, Northwestern University Earl P. Benditt Award Lecture: From pathophysiology of vascular malformations towards therapeutic trials - Florence R. Sabin Award Presentation: Naomi Chesler, University of California, Irvine | |
9:00-10:00pm | Welcome Reception | |
Day 2 – Monday, October 16 | ||
7:30-8:30am | NETWORKING 101: Learn networking skills, perfect your elevator talk, and learn how to use the app as a communication tool | |
8:30-10:00am | HEMOGENIC ENDOTHELIUM/ ENDOTHELIAL DIVERSITY Origins of hematopoietic stem cells from hemogenic endothelium in the mouse embryo Short talk: Deciphering the function of the N-glycan code during the endothelial-to-hematopoietic transition Short talk: A set of short-lived sprouting vein cells fuels rapid growth of the postnatal liver Roles of the somite in hematopoietic stem cell specification | PRO-INFLAMMATORY SIGNALING How endothelial cells regulate the inflammatory response Short talk: Single cell transcriptional-epigenetic profiling and compartmental cellular proteomics demonstrate that HIV-Nef extracellular vesicles modulate human macrophage heterogeneity to promote atherosclerosis Short talk: Increased endothelial levels of RNA binding protein Elavl1 (HuR) in atherogenic conditions post-transcriptionally defines cell phenotype and supports T cell survival Endothelial control of innate immune signaling during shock |
10:00 – 10:30am | COFFEE BREAK | |
10:30am- 12:00pm | STEM CELLS/ORGANOIDS/IN VITRO MODELS Reconstructing organotypic vasculature and mesenchyme from human iPSCs Short talk: Modeling the multicellular and flow control perspective of the blood-brain barrier Short talk: Transcription factor-driven generation of human vascular organoids Efficiently generating human artery and vein cells from pluripotent stem cells to study deadly biosafety level 4 viruses
| VASCULAR MATRIX Proteolysis and proteolytic mechanisms in vascular remodeling Regulation of endothelial cell dynamics and vascular remodeling by cell-ECM interactions Proteomic analysis of aortic aneurysm at single-cell resolution |
12:00 – 1:30pm | Lunch and Learn for Trainees and Meet the Exhibitors for PIs | |
1:30 – 3:00pm | BLOOD FLOW REGULATION Cutaneous microvascular endothelial dysfunction in young adult e-cigarette users Short talk: Exercise training improves coronary vasodilation in the ischemic heart through recruitment of Kv7 channels Short talk: Endothelial Pannexin1 overexpression impairs ischemic stroke outcome in a sex-dependent manner A vascular origin of cardiac disease in obesity | RESOLUTION OF INFLAMMATION Human leukocyte production of Resolvin D3, Resolvin D4 and novel Resolvins Short talk: Meningeal lymphatic endothelial cell regulation of T cell function and migration Short talk: Long noncoding RNA regulation of inflammation in atherosclerosis Lipoxins modulate leukocyte function differentially in health and disease |
COFFEE BREAK | ||
3:15pm – 5:00pm | VASCULAR MALFORMATIONS Decoding the brain's vasculature and arteriovenous malformations: A prelude to precision therapy Short talk: Mek inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ Short talk: Sirolimus in slow-flow vascular malformations: preliminary results of the European multicentric phase III trial Mechanisms of neuroinflammation in brain vascular malformations Short talk: iPSC-derived EC to model port wine birthmark in a microphysiological system | |
7:00 – 7:30pm | Evening NANO-TALKS - Highlighting Monday Posters | |
7:30 – 10:00pm | Evening POSTER SESSIONS | |
Day 3 – Tuesday, October 17 | ||
7:30 – 8:30am | Breakfast and Career Development Round Table: Industry as a Career Path | |
8:30 – 10:00am | CARDIOVASCULAR CELL BIOLOGY Sculpture lessons – learning from the zebrafish how we Short talk: Obesity in angiogenesis and regenerative lung growth Short talk: First proximity proteomic map of vascular CaV1.2 Building a functional heart – from single cells to 3D | SYSTEMIC INFLAMMATORY NETWORKS Lifestyle, the vasculature, and the brain Short talk: Pro-inflammatory macrophage IL-12 and IL-23 modulate vascular smooth muscle cell differentiation via the histone methyltransferase SETD4 Short talk: Adipocyte extracellular vesicles mediate obesity-accelerated atherosclerosis Innate immunity within vessels |
10:00 – 10:30am | COFFEE BREAK | |
10:30am- 12:00pm | LYMPHATIC DEVELOPMENT Developmental programming of lymphatic endothelial cell progenitors Short talk: Inhibiting Foxc2 to dampen epsin expression mitigates obesity and lymphedema Short talk: Requirement for lymphatic endothelial Notch4 in murine male livers Short talk: Piezo2 regulation of lymphangiogenesis Short talk: Rictor induces AKT signaling to regulate lymphatic valve formation and maintenance | MECHANICAL FORCES AND THE VASCULATURE Cell mechanics and cardiovascular morphogenesis Short talk: DLC1 promotes mechanotransductive feedback for YAP via Rho GAP-mediated focal adhesion turnover Short talk: Novel roles for centriolar protein WDR90 in endothelial cells and cardiac tissue Flow directed endothelial cell planar polarization and signaling |
12:00 – 1:30pm | Lunch and DEI Round Table: Addressing the Disparity in Grant Funding for Women and Underrepresented Groups | |
1:30 – 3:30pm | MCS President’s Symposium: Novel Insights from Spatiotemporal Calcium Imaging in the Microcirculation Organized by Pooneh Bagher, University of Nebraska Medical Center Calcium imaging in the microcirculation: A historical perspective May the force be with you: Endothelial Piezo1 and blood flow control Spatiotemporal regulation of CaV1.2 calcium signaling in vascular smooth muscle Calcium signaling in pulmonary veins- A new paradigm Trpv4-mediated regulation of lymphatic vascular function and dysfunction | |
3:30pm – 4:15pm | MCS – Landis Award Lecture and Presentation – Sensing flow/shear stress in the microcirculation: the power of observation Akos Koller, Semmelweis University, Hungarian University of Sports Science, and New York Medical College | |
4:15 – 5:00pm | MCS – Emerging Topics in Microcirculation Regulation of hemostasis by endothelial glycocalyx The blood-brain barrier in systemic inflammation Short talk: A novel approach to restore endothelial glycocalyx in sepsis using liposomal nanocarriers of preassembled glycocalyx, followed by quantitative analysis of endothelial glycocalyx with sidestream dark field image Short talk: Oxidation of low-density lipoprotein (oxLDL) by hemoglobin causes lung microvascular endothelial barrier dysfunction via lectin-like oxLDL receptor-1 (LOX-1) | |
7:00 – 7:30pm | Evening NANO-TALKS - Highlighting Tuesday Posters | |
7:30 – 10:00pm | Evening POSTER SESSIONS | |
Day 4 – Wednesday, October 18 | ||
7:30-8:30am | Breakfast and Career Development Round Table on Managing Career Transitions | |
8:30-10:00am | ADV. ENGINEERING MODELS & IMAGING TECHNIQUES Engineering vascularized organoids and organ-specific tissues Short talk: Advancing custom patterned vessels in engineered human myocardium as a revascularization co-therapy for heart regeneration Short talk: Perfusable vascular organoids for blood-brain barrier modeling Building vasculature in engineered organs | AGEING, METABOLISM AND THE VASCULATURE Decoding communication across the aging brain vasculature Andrew Yang, University of California San FranciscoShort talk: Nucleoporin93 (Nup93) limits YAP activity to prevent endothelial cell senescence and dysfunction Tung D Nguyen, University of Illinois at Chicago College of Medicine Short talk: The VEGF-A isoforms switch and opposing VEGF receptors binding as mechanisms of impaired inflammatory angiogenesis in the context of advanced aging Altered endothelial metabolism drives cardiac dysfunction in diabetes |
10:30am – 12:00pm | VASCULAR BIOMATERIALS AND BIOENGINEERING Blood flow regulation of early cardiac development Short talk: Growth of an engineered vascular graft in simulated repair of absent pulmonary artery branch Short talk: Sex differentiating factors in the pathophysiology of human ascending aortic disease Short talk: Precision nanomedicine targeting novel endothelial mechano-sensing mechanisms to treat vascular diseases Short talk: Biophysical rejuvenation of mesenchymal stem cells for enhancing vascular regeneration
| 3D IMAGING AND ORGANOTYPIC VASCULATURE Principles of skin vasculature and endothelial cell dynamics captured by imaging live mice Short talk: Defining the cellular complexity of the zebrafish bipotential gonad Short talk: Human bone-specific endothelial cells mediate osteogenesis via KIT ligand Genetic compensation during vascular development and regeneration |
12:00 - 1:30pm | Lunch and DEI Round Table on Grant Writing for Internationally Trained Scientists | |
1:30 – 3:00pm | INFLAMMATION IN CANCER Short talk: The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation and thrombosis Short talk: Circulating factors as key contributors to endothelial dysfunction following anticancer therapy Short talk: Endothelial cell-selective adhesion molecule alters tumor microenvironment and promotes tumor growth in a mouse model of diastolic heart failure | NEUROVASCULAR UNIT AND DISEASE Wnt/b-catenin signaling in neurovascular unit maturation Dritan Agalliu, Columbia University Irving Medical CenterShort talk: Hypoxia acts as an accelerant of Cerebral Cavernous Malformations disease through neuroinflammation signaling Helios A Gallego-Gutierrez, UCSD Short talk: Moderately advanced age exacerbates neuroinflammation, blood-brain barrier leakage, and behavioral deficits in a mouse model of COVID-19 Short talk: Combined single-cell and intranuclear CITE-seq reveals transcriptional association of reduced TDP-43 in brain vascular endothelial cells Short talk: Targeting metabolic alterations to prevent moyamoya-like cerebrovascular disease |
3:00 – 3:30pm | COFFEE BREAK | |
3:30 – 5:00pm | NAVBO AWARD LECTURES AND PRESENTATIONS Stephen Schwartz Award for Outstanding Mentorship Presentation – Supported by Vascular Pharmacology Springer Lecture and Award Presentation - Hemodynamic regulated genes that alter vascular development Judah Folkman Award in Vascular Biology Lecture – Metabolic guidance of angiogenesis: principles and mechanisms | |
7:00 – 7:30pm | Evening NANO-TALKS - Highlighting Wednesday Posters | |
7:30 – 10:00pm | Evening POSTER SESSIONS | |
Day 5 – Thursday, October 19 | ||
8:30 - 8:45 am | Presentation of the Poster Awards | |
8:45am – 1:00pm | General Session: PLASTICITY OF THE VASCULATURE Molecular and functional heterogeneity of bone endothelial cells Short talk: Cell cycle-dependent regulation of endothelial cell chromatin availability and transcription factor activity during arterial-venous specification Short talk: Evolutionarily conserved mechanisms drive ontogeny and arterial endothelial heterogeneity of the lung vasculature Short talk: Hematopoietic potential of the endocardium in zebrafish embryos Mapping the Transcriptional and Epigenetic Basis of Endothelial Maturation in the Mouse Brain Effector roles of platelets in Aortic Aneurysms Short talk: Non-canonical telomerase reverse transcriptase controls osteogenic reprogramming of aortic valve cells through STAT5 Short talk: Molecular signature of smooth muscle cell expansion in hypoxia-induced pulmonary hypertension: identification of Cthrc1 as a possible target Short talk: Longitudinal mapping of lung regeneration reveals the emergence of injury-associated endothelial cell states Mechanoepigenetic control of smooth muscle cell identity and functions |
The speakers listed above (except for award lectures) will give a 20-minute presentation and then participate in a 10-minute question and answer period.
Each session above, except for the MCS President’s symposium and Award Lectures, will also include short talks from selected abstracts – many of these will be trainees in order to increase the participation of young investigators in the meeting program.