Paul S. Frenette, M.D.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research
Albert Einstein College of Medicine
New York, NY

Primary Research: 
Our laboratory is interested in understanding the cellular and molecular constituents of hematopoietic stem cell niche. We have identified differential functions of vascular niches in the bone marrow. We are also interested in dissecting the mechanisms mediating vascular occlusion in sickle cell disease, a process in which we have identified a key role for activated neutrophils.

Lab Motto:  In vivo veritas

Find more information on the web: http://www.einstein.yu.edu/labs/paul-frenette/

Recent Publications:

1. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.   Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A,Frenette PS. Nat Med. 2014 Oct 19. doi: 10.1038/nm.3707. [Epub ahead of print] PMID: 25326802 [PubMed - as supplied by publisher]

2. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Mendelson A,Frenette PS. Nat Med. 2014 Aug;20(8):833-46. doi: 10.1038/nm.3647. Review. PMID: 25100529 [PubMed - indexed for MEDLINE]

3. Stem cells: Reprogramming finds its niche. Lucas D, Frenette PS.  Nature. 2014 Jul 17;511(7509):301-2. doi: 10.1038/nature13516. Epub 2014 Jul 2. No abstract available. PMID: 25030164 [PubMed - indexed for MEDLINE]

4. Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche.  Hanoun M, Zhang D, Mizoguchi T, Pinho S, Pierce H, Kunisaki Y, Lacombe J, Armstrong SA, Dührsen U, Frenette PS.  Cell Stem Cell. 2014 Sep 4;15(3):365-75. doi: 10.1016/j.stem.2014.06.020. Epub 2014 Jul 10.  PMID: 25017722 [PubMed - in process]

5. Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.  Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM,Frenette PS.  Dev Cell. 2014 May 12;29(3):340-9. doi: 10.1016/j.devcel.2014.03.013.  PMID: 24823377 [PubMed - indexed for MEDLINE]

6. Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage.  Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM.  Dev Cell. 2014 May 12;29(3):330-9. doi: 10.1016/j.devcel.2014.03.014.  PMID: 24823376 [PubMed - indexed for MEDLINE]

7. Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease.  Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS.  Blood. 2014 Jun 12;123(24):3818-27. doi: 10.1182/blood-2013-10-529982. Epub 2014 Mar 11.  PMID: 24620350 [PubMed - indexed for MEDLINE]

8. Arteriolar niches maintain haematopoietic stem cell quiescence.  Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A, Frenette PS.  Nature. 2013 Oct 31;502(7473):637-43. doi: 10.1038/nature12612. Epub 2013 Oct 9.  PMID: 24107994 [PubMed - indexed for MEDLINE] Free PMC Article

9.  Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies.  Manwani D, Frenette PS.  Blood. 2013 Dec 5;122(24):3892-8. doi: 10.1182/blood-2013-05-498311. Epub 2013 Sep 19.  PMID: 24052549 [PubMed - indexed for MEDLINE]

10. Autonomic nerve development contributes to prostate cancer progression.  Magnon C, Hall SJ, Lin J, Xue X, Gerber L, Freedland SJ, Frenette PS.  Science. 2013 Jul 12;341(6142):1236361. doi: 10.1126/science.1236361.  PMID: 23846904 [PubMed - indexed for MEDLINE] Free Article