BBHV - Basic Biology of Blood, Heart and Vasculature

The BBHV reviews a wide range of grants focused on cardiovascular disease, hematopoiesis, and vascular biology. Applications focused on basic molecular and cellular mechanisms and physiology of blood, heart and vascular cells and tissues in both normal and pathologic conditions are appropriate to submit to this study section. The applications in BBHV typically use cellular, biochemical, biophysical, immunological, genetic, pharmacological, and molecular biological approaches in in vitro and in vivo experimental models.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DTCS/IVBH/BBHV

BINP - Brain Injuries and Neurovascular Pathologies

The Brain Injury and Neurovascular Pathologies (BINP) Study Section evaluates applications that investigate the mechanisms of acute brain injury, as well as test potential therapies in animal models of ischemic stroke, cerebral ischemia, traumatic brain injury, and related vascular disorders, including cerebral amyloid angiopathy, intracerebral hemorrhage, microvascular damage, vascular malformations, vascular cognitive impairment, and alterations in the blood-brain barrier. Studies should be based on a solid scientific premise supported by preliminary data and a rigorous, comprehensive experimental approach. Having conceptually innovative hypotheses, and an exceptional investigative team and research environment are expected.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DNDA/CN/BINP

BMBI- Biomaterials and Biointerfaces Study Section

The BMBI study section reviews applications with a focus on biologically relevant research in materials science and the interaction of material surfaces with biological systems such as cells and organoids. Areas of interest include the design, and synthesis of biomaterials; the use of biomaterials in tissue engineering; characterization of new or existing biomaterials; and the interactions of biomaterials with proteins, membranes, cells, and tissues. Many applications reviewed in this study section focus on building bioengineered blood vessel networks and vascular grafts or on building bioengineered vascularized tissues.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DBIB/BBBT/BMBI

CDD - Cardiovascular Differentiation and Development

The Cardiovascular Differentiation and Development (ZRG1 CDD 81) Special Emphasis Panel (SEP) reviews basic research applications related to development and differentiation of cardiovascular systems that include heart, vascular and lymphatics. Experimental approaches and technologies typically include, but are not limited to cellular, molecular, genetic, genomic/proteomic and use of transgenic models.

Studies utilize varied experimental model systems including mouse, chick, zebrafish, xenopus and drosophila, among others. ZRG1 CDD 81 reviews molecular and genetic studies of human cells and tissues as well as the evaluation of bioengineered cells and tissues in the context of cardiac, vascular or lymphatic systems.

• Cardiac development, including: commitment and differentiation of cardiac cell phenotypes; looping morphogenesis; cardiac chamber specification, valvulogenesis; epicardial and coronary vessel development; neural crest in developing heart and great vessels; cardiac conduction system; embryonic cell processes, cellular signaling and transcriptional regulation in heart development, structural or mechanical controls of cardiac development, normal developmental cardiac hypertrophy
• Vascular development, including: origin, commitment and differentiation of endothelial and smooth muscle cell populations; vasculogenesis and angiogenesis; patterning and organization of the vascular system; vascular remodeling in the postnatal organism; neovascularization in adults recapitulating embryonic and fetal processes.
• Lymphatic development including: differentiation, development and organization of the lymphatic vascular system; molecular and cellular mechanisms of lymphangiogenesis; lymphedema; structural and mechanical influences on lymphangiogenesis
• Stem cells: differentiation of embryonic and adult stem cells into cardiomyocytes, endothelium, smooth muscle and other components of the cardiovascular system; resident stem cells in regeneration and repair of myocardium and vasculature in vivo
• Human genetics of cardiac and vascular malformations; studies related to human congenital defects of cardiovascular system; modeling of human developmental cardiovascular diseases in different organisms.
• Evaluation of bioengineered tissue in the context of developing, differentiating or regenerating cardiac, vascular or lymphatic systems.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DTCS/RCCS/ZRG1CDD81

HTBT- Hemostasis, Thrombosis, Blood Cells and Transfusion

HTBT reviews applications involving basic and applied aspects of hemostasis, thrombosis, hematopoiesis, red blood cells, white blood cells, platelets, transfusion, blood rheology and hemodynamics, and endotheliopathy. Studies using cellular, biochemical, biophysical, immunological, genetic, pharmacological and molecular biological approaches to define normal and pathological processes are reviewed. Applied aspects of normal and abnormal hematopoiesis, as well as applied aspects of the formed elements of the blood are also reviewed. Additional areas of review include hematopoietic stem cells, hematopoietic growth factors and their receptors, iron and heme metabolism, blood cell cytoskeleton biology, myeloid biology, transfusion medicine and gene therapy. HTBT does not review applications related to leukemia.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DTCS/IVBH/HTBT

IVPP - Integrative Vascular Physiology and Pathology

The IVPP study section reviews applications that seek to understand basic physiological and pathophysiological cellular and molecular mechanisms involving both the blood and lymphatic vasculatures, as well as applications that assess the effectiveness and efficiency of novel pre-clinical and clinical therapeutic interventions to improve tissue/organ function and overall systemic health in diseased states by targeting components of these vascular systems. Applications focused on vascular remodeling, vascular mechanics (e.g., strain/stress, PWV) and structure, and measurements of vascular contractility and relaxation, including myogenic tone and flow-mediated dilation are appropriate to submit to this study section.  Applications that focus on the biology of the endothelium, vascular smooth muscle cells, and perivascular adipose tissue, and vascular homeostasis and dysfunction in experimental models, including hormonal regulation of hypertension, integrated neural-humoral control of circulation, regional hemodynamics, lymphatic circulation, and microcirculation are also considered. The specific disease, and whether an application utilizes one or multiple experimental approaches, i.e., in vivo, in vitro, and/or ex vivo, do not affect the overall impact of the project, as long as the proposed work is well founded and supported by strong preliminary data.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DTCS/IVBH/IVPP

RIBT- Respiratory Integrative Biology and Translational

The RIBT study section reviews integrative, translational as well as patient-oriented research involving pulmonary vascular biology and disease, neural control of breathing, respiratory biophysics and biomechanics, imaging of lung and chest wall, and upper airway physiology and control of respiration during sleep. Clinical studies and trials related to pulmonary physiology are reviewed in RIBT. Methods may include molecular and cellular approaches, normal and genetically modified animal models, human subjects and mathematical modeling. Emphasis is often on physiologic, integrative, and translational approaches, including combining model simulations with experiments, interactions between and across tissues and cell types, and hierarchical approaches that link micro- and macro-level responses.

For more information, visit the web page: https://public.csr.nih.gov/StudySections/DTCS/RCCS/RIBT