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Funding for this conference was made possible (in part) by 1R13HL178275-01 from the National Heart Lung and Blood Institute (NHLBI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Lymphatic Forum 2025 Logo

NAVBO will once again Co-Sponsor the Lymphatic Forum

Abstract deadline extended to March 24, 2025 at 5:00pmEDT

Join us in Chicago from June 12-14 for the sixth presentation of the Lymphatic Forum, co-sponsored by NAVBO and LE&RN, the Lymphatic Education & Research Network.

NAVBO and LE&RN members, as well as associates at Northwestern University, University of Chicago, and the University of Illinois, Chicago, are eligible for discounted rates.

More details about the meeting can be found on the Lymphatic Forum web site.

NAVBO Trainee members are eligible for Travel Awards - indicate within the abstract submission system that you are applying for an award - deadline is March 24You will be required to upload your CV

Program

Lymphatic Forum 2025 – Preliminary Program 

Day 1 – Thursday, June 12 
8:20-8:30am  Welcome Remarks: Tsutomu Kume, Northwestern University
8:30-12:00pm  Plenary Session 1 – Lymphatics Development and Differentiation
Chair: Hyun-Min Jung, University of Illinois, Chicago
8:30-9:00am Novel insights into lymphatic-associated organs and cells from the zebrafish
Brant Weinstein (NICHD/NIH)
9:00-9:30am Mechanisms of lymphatic vascular specialization
Tatiana Petrova (University of Lausanne, Switzerland)
9:30-10:00am Developmental evolution and plasticity of lymphatic endothelial cells
Ben Hogan (Peter MacCallum Cancer Centre, Australia)
10:00-10:30am Coffee Break
10:30-11:00am Mapping chromatin landscape and regulatory logic behind lymphatic endothelial cell differentiation
Kaska Koltowska (Uppsala University, Sweden)
11:00-11:30am A novel neuro-lymphatic communication regulates lymphatic development and function
Xiaolei Liu (Temple University)
11:30am-12:00pm Short Talk - Lyve1-driven NrasQ61R expression causes edema, enlarged lymphatic vessels, and hepatic vascular defects in embryonic mice
Charles McDaniel, Cincinnati Children's Hospital Medical Center
Short Talk - Connexin 37 and cell cycle regulation of lymphatic valve morphogenesis
Madeline Jackson, University of Virginia
12:00-1:30pm Lunch (on your own)

For Trainees: Career Development Round Table – Learning networking skills
($10 pre-registration required/includes lunch)
1:30-5:00pm  Plenary Session 2 – Lymphatic Fluid Regulation
Chair: Tsutomu Kume, Northwestern University
1:30-2:00pm Unraveling the meningeal lymphatics and their connections for cerebrospinal fluid drainage
Gou Young Koh (KAIST, South Korea)
2:00-2:30pm High resolution in vivo imaging of cerebrospinal fluid clearance to lymphatics
Steven Proulx (University of Bern, Switzerland)
2:30-3:00pm Short Talk - Distinct Role of Dural and Leptomeningeal Macrophages in Maintaining Cerebrospinal Fluid Drainage to Meningeal Lymphatic Vessels
Shan Liao, University of Calgary
Short Talk - Identification of Slc22a1 (Oct1) as a novel marker of lymphatic muscle cells
Michael Detmar, ETH Zurich
3:00-3:30pm Break
3:30-4:00pm Unique properties of lymphatic muscle cells enable spontaneous, phasic contractions
Michael Davis (University of Missouri)
4:00-4:30pm The function of TSC protein in lymphatics
Ying Yang (University of South Florida)
4:30-5:00pm Short Talk - Store-operated calcium entry in mouse lymphatic muscle cells: A new paradigm to explore
Soumiya Pal, University of Missouri
Short Talk - The thrombin receptor PAR1 orchestrates Changes in Lymphatic endothelial cell junction morphology to augment lymphatic drainage during lung injury
Chou Chou, Weill Cornell Medicine
5:30-7:30pm Welcome Dinner
7:30-9:30pm Poster Presentation 1
Day 2 – Friday, June 13
8:30am-12:00pm  Plenary Session 3 – Lymphatic-Immune Crosstalk
Chair: Kathleen Caron, University of North Carolina at Chapel Hill
8:30-9:00 Immunological implications of lymphatic function in tumors
Melody Swartz (University of Chicago)
9:00-9:30am Uncovering roles for lymph nodes in metastatic progression and tumor immunotherapy
Nathan E. Reticker-Flynn (Stanford University)
9:30-10:00am Navigating immunity: Leukocyte-lymphatic crosstalk
Cornelia Halin Winter (ETH Zurich, Switzerland)
10:00-10:30am Coffee Break
10:30-11:00am  Lymphatic drainage from the intestine
Gwendalyn J. Randolph (Washington University)
11:00-11:30am Regulation of lymphatic function during acute lung injury
Hasina Outtz Reed (Weill Cornell)
11:30am-12:00pm  Short Talk - Modulation of lymphatic endothelial nitric oxide regulates the progression of cardiometabolic heart failure
Skylar Loeb, University of Virginia School of Medicine
Short Talk - Investigating the mechanisms of Helicobacter hepaticus mediated lymphangiogenesis and tertiary lymphoid structure formation
Katelyn Wolfgang, University of Pittsburgh
12:00-1:30pm Lunch (on your own)
For Trainees: Career Development Round Table – Managing Your Career
($10 pre-registration required/includes lunch)
1:30-4:20pm  Plenary Session 4 – Lymphatics in Metabolism
Chair: Guillermo Oliver, Northwestern University
1:30-2:00pm Ameliorating metabolic syndrome: Foxc2 as novel target
Hong Chen (Harvard Medical School)
2:00-2:30pm Mechanisms of lymphatic growth and specialization
Michael Potente (Berlin Institute of Health, Germany)
2:30-3:00pm Collecting lymphatic vessel dysfunction in obesity and dyslipidemia
Jorge Castorena-Gonzalez (Tulane University)
3:00-3:20pm Break
3:20-3:50pm Shape-shifters in the vasculature
Susan Quaggin (Northwestern University)
3:50-4:20pm Short Talk - Lymphatic endothelial Piezo1–TRPV4 signaling in obesity
Yen-Lin Chen, University of Virginia
Short Talk - The functional roles of TGFβ signaling in regulating cardiac lymphangiogenesis and cardiac repair after myocardial ischemia
Esteban Delgado, Temple University
4:20-4:30pm Break
4:30-6:00pm  Plenary Session 5 – Unsolved Issues and Gaps in Lymphatic Disease
Chair: Carrie Shawber, Columbia University
4:30-4:50pm Pharmacologic therapy for regional lymphedema: A systemic disease?
Stanley Rockson (Stanford University)
4:50-5:10pm Podoplanin hetero-insufficiency mice with inflammation in the jejunum demonstrates a good animal model of congenital protein-losing enteropathy with lymphangioectasia 
Toshio Ohashi (Shinshu University, Japan)
5:10-5:30pm Management of lymphatic anomalies: development of novel therapies and challenges
June Wu (Columbia University)
5:30-6:00pm Panel Discussion among above speakers
6:00-8:00pm Dinner (on your own)
8:00-10:00pm Poster Presentation 2
Day 3 – Saturday, June 14
8:15-9:15am Young Investigator Session
Chairs: Olivia Crawford, University of Connecticut and Mohammad Abdallah, Monash University
Short Talk - A novel RAS inhibitor suppresses abnormal characteristics induced by NRAS Q61R in vitro
Sara Alharbi, Cincinnati Children’s Hospital Medical Center
Short Talk - The role of the lymphatic system in cardiac growth, repair and regeneration
Gal Perlmoter, Weizmann Institute
Short Talk - The Notch3+ stroma in gut lymphatic-muscle development and stem cell homeostasis
Liqing Huang, Cornell University
Short Talk - Metabolically driven iPSC differentiation to generate robust and functional lymphatic endothelial cells
Donghyun Jeong, University of Notre Dame
9:15am-12:00pm Concurrent Session 1 (Disease-oriented)
Lymphatic Disease Detection,
Therapeutic Innovations, Clinical Trials
Chair: June Wu, Columbia University
Lymphatic Malformation and Pathobiology and Clinical Trials
Chair: Luisa Iruela-Arispe, Northwestern Univ
9:15-9:45am Gaps in the current diagnosis, treatment, and control of Lymphatic Filariasis, a human tropical parasite
Ramaswamy Kalyanasundaram (UIC)
Lymphatic anomalies: From genes and pathophysiology towards therapeutic trials
Miikka Vikkula (UCLouvain, Belgium)
9:45-10:15am Surgical management of lymphedema
David Chang (University of Chicago)
Proteostasis defects downstream of PI3K hyperactivation in lymphatic anomalies; A novel therapeutic target
Carrie Shawber (Columbia University)
10:15-10:45am Leveraging biomaterials to improve lymphatic formation and function in lymphedema
J. Brandon Dixon (Georgia Tech)
Medical management of lymphatic anomalies (Clinical trials and future trials)
Denise Adams (Children’s Hospital of Philadelphia)
10:45-11:00am Coffee Break
11:00-11:30am Diagnosis of lymphatic disease with MR lymphangiography
Andreas Loening (Stanford University)
A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels
Michael Dellinger (UT Southwestern)
11:30am-12:00pm Intestinal lymph interactions in metabolic control
Natalie Trevaskis (Monash University, Australia)
Cerebral venous blood flow regulates brain fluid clearance via meningeal lymphatics
Jean-Leon Thomas (Yale University School of Medicine)
12:00-12:30pm Short Talk - Preliminary results of the European multicentric phase III trial regarding sirolimus in slow-flow vascular malformations
Laurence Boon, Saint-Luc University Hospital
Short Talk - Lymphatic pulsing anomalies preceding dermal backflow appearance and clinical breast cancer-related lymphedema
Melissa Aldrich, UTHealth
Short Talk - Marfan Syndrome impairs the formation and function of lymphatic vessels in the mitral valves causing the progression of myxomatous valve degeneration
Can Tan, Northwestern University
Short Talk - KRAS mutations in lymphatic malformations degrade lymphatic valves through the plasminogen activator pathway and MMPs
Diandra Mastrogiacomo, University of South Florida
12:30-2:00pm Lunch (on your own)
2:00-4:45pm Concurrent Session 2 (Disease-oriented)
Lymphatics, Cancer, and Metastasis
Chair: Jan Kitajewski, UIC
Lymphatic Dysfunction in Human Diseases
Chair: Stanley Rockson, Stanford University
2:00-2:30pm Aging-induced changes in lymphatic system function
Timothy Padera (Harvard Medical School)
Mechanisms underlying form and function of the contractile gut lymphatic system
Natasza Kurpios (Cornell University)
2:30-3:00pm Cell migration in lymph node mimicking microenvironments
Susan Thomas (Georgia Tech)
New insight about the functional roles of lymphatics in cardiac growth and repair
Guillermo Oliver (Northwestern University)
3:00-3:30pm Tumor microenvironmental dynamics driving local and systemic T cell responses
Dennis Jones (Boston University)
Phenotyping and genotyping of primary lymphatic anomalies
Pia Ostergaard (St George’s University)
3:30-3:45pm Coffee Break
3:45-4:15pm Microphysiological systems for lymphatic and cancer research
Esak Lee (Cornell University)
Genomics informs precision medicine for individuals with lymphatic anomalies
Sarah Sheppard (NIH)
4:15-4:45pm Short Talk - Transcriptomic analysis of tumor LECs and migratory leukocytes – A comparison between cold and hot tumors
Marina Thoma, ETH Zurich
Short Talk - Comprehensive 3D statistical atlases for predicting lymphatic drainage in breast cancer and cutaneous melanoma
Hayley Reynolds, The University of Auckland
Short Talk - Liver lymphatic changes in biliary atresia from diagnosis to transplant
Alyssa Goldberg, University of Colorado School of Medicine
Short Talk - Adipose tissue expansion in obesogenic conditions can occur via Piezo2 in capillary lymphatic endothelium
Zuzanna Juskiewicz, University of Virginia School of Medicine
4:45-5:00pm Poster Award Presentations
Closing Remarks
Registration
Abstract Submission
Venue and Hotel

Deadline Extended
Abstracts due March 24, 2025

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