Members’ Labs

Andrew Vaughan, PhD

Associate Professor
Biological Sciences
University of Pennsylvania

Primary Research:

The Vaughan lab’s research is focused on defining and understanding the relevant cell types and molecular mechanisms by which the mammalian lung is able to regenerate after severe injury. We are especially interested in elucidating the means by which epithelial and endothelial progenitor cells contribute to the restoration of airway and alveolar units after viral pneumonia and acute respiratory distress syndrome.

Laboratory web site URL:

https://www.vaughanlab.com/

Recent Presentations:

FASEB Lung Epithelium in Health and Disease
NAVBO Symposium on The Role of Microcirculation in Lung Pathology
Mt Sinai IRM Invited Speaker
Fusion Conference - Epithelial Mesenchymal Interactions in Lung Development and Fibrosis

Collaborative Relationships:

Michael May Lab

Laboratory Motto:

We breath science.

Members of the Laboratory

Recent Publications

Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nat Commun. 2024 May 18;15(1):4235. doi: 10.1038/s41467-024-48589-3. PubMed PMID: 38762489; PubMed Central PMCID: PMC11102455.
Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE. TGF-βR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Sci Transl Med. 2024 Jan 31;16(732):eadg6229. doi: 10.1126/scitranslmed.adg6229. Epub 2024 Jan 31. PubMed PMID: 38295183.
Weiner AI, Zhao G, Zayas HM, Holcomb NP, Adams-Tzivelekidis S, Wong J, Gentile ME, Reddy D, Wei J, Palashikar G, Quansah KK, Vaughan AE. ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury. Cell Rep. 2022 Dec 13;41(11):111805. doi: 10.1016/j.celrep.2022.111805. PubMed PMID: 36516758; PubMed Central PMCID: PMC9808897.
Cully MD, Nolte JE, Patel A, Vaughan AE, May MJ. Loss of Lymphatic IKKα Disrupts Lung Immune Homeostasis, Drives BALT Formation, and Protects against Influenza. Immunohorizons. 2024 Jul 1;8(7):478-491. doi: 10.4049/immunohorizons.2400047. PubMed PMID: 39007717; PubMed Central PMCID: PMC11294277.