Dr. Giachelli is the Professor and Chair of Bioengineering, Adjunct Professor of Pathology and Oral Health Sciences at the University of Washington, Seattle, WA.The major goals of Dr. Giachelli's lab are to develop molecular and cellular bioengineering approaches to prevent and treat ectopic calcification and promote healing, biocompatibility, tissue regeneration and biomineralization.
The Fish lab investigates the molecular mechanisms that control endothelial cell biology..
Dr. Elena Aikawa is Associate Professor of Medicine at Harvard Medical School. She is also Principle Investigator at the Center for Excellence in Vascular Biology in the Harvard Medical School's New Research Building (NRB Lab) and Director of the Vascular Biology Program at the Center for Interdisciplinary Sciences (CICS) at Brigham and Women's Hospital in Boston, Massachusetts.
One focus of the lab is interrogating the human and mouse genomes for functional non-coding sequences. For example, we have used computational biology and next generation sequencing to identify thousands of conserved CArG boxes (CArGome), to which the SRF transcription factor binds.
Dr. Liu's lab focuses on investigation of cellular and molecular mechanisms underlying restenosis and abdominal aortic aneurysm. Abnormal behavior of vascular smooth muscle cells is implicated in both disease processes, albeit through different phenotypic presentations.
The D’Amore laboratory has a long history of interest in understanding vascular development and pathology, particularly as it relates to the retina in pathologies such as diabetic retinopathy and wet age-related macular degeneration. Over the past two decades she has focused on the role of VEGF in these process and she and her colleagues contributed to the work that forms the basis for the use of anti-VEGF therapies in the eye.
Our laboratory is interested in understanding the cellular and molecular constituents of hematopoietic stem cell niche. We have identified differential functions of vascular niches in the bone marrow.
Cardiovascular Mechanobiology and Nanomedicine
Neurovascular interactions in the brain, eye and peripheral nervous system
Research in the Milewicz laboratory has three components. The first component is recruiting and clinically characterizing families with multiple members with vascular disease, including thoracic aortic aneurysms, acute aortic dissections, cerebral aneurysms, and early onset ischemic strokes.
Dr. Boehm's primary research interests are in vascular biology and the genetics of vascular remodeling in human diseases.
A major focus of our research program is the role of the extracellular matrix (ECM) in cardiovascular homeostasis and disease. We are pursuing our studies using mouse models of Marfan syndrome (MFS), a multi-system disease caused by mutations in the ECM component and TGFβ regulator fibrillin-1, and a combination of genetic, pharmacological, ex vivo and computational approaches.
